Neeraj   Manhas, Ph.D

Department Department of Mathematics
Designation Assistant Professor *
Educational Qualification Ph.D, Post doc.
E-Mail nmanhas.maths@nitrr.ac.in & mannumanhas@gmail.com,
Contact Number 7006143838
Areas of Interest

Mathematical/Computational Physiology. 

Cell Calcium Handling: Excitable and Nonexcitable Cells.

Cardiology. 

Mitochondrial Bioenergetics , Reactive Oxygen species & Ischemic Heart disease. 

Publications
  • Publications in International journals (First and Corresponding Author):
  • Neeraj Manhas, Quynh V Duong, Pilhwa Lee, Joshua D Richardson, John D Robertson, Michael A Moxley, and Jason N Bazil, “ Computationally modeling mammalian succinate dehydrogenase kinetics identifies the origins and primary determinants of ROS Production. Journal of Biological Chemistry, Elsevier, American Society for Biochemistry and Molecular Biology. August, 28, 2020,295(45):15262-15279,(SCI,IF 5.2). PMID:32859750 doi: 10.1074/jbc.RA120.014483.(First Author) (Q1 Category,Pages 37  Manuscript plus Supplementary Material). ( This is the Best Paper from the computational side & Present in the 2020 retrospective collection of JBC).
  • Neeraj Manhas, James Sneyd and K. R. Pardasani “Modelling the transition from simple to complex Ca2+ oscillations in the pancreatic acinar cells. Journal of Biosciences, Springer. 39(3), (2014), 463-484. (SCI, IF=2.2). PMID 24845510, doi:10.1007/s12038014-9430-3.(First and corresponding Author) (Q1 Category, Pages 22  Manuscript ). 
  • Neeraj Manhas and N. Anbazhagan “A Mathematical Model of Intricate Calcium dynamics and Modulation of Calcium Signalling by Mitochondria in Pancreatic Acinar cells” Chaos Solitons & Fractals, Elsevier. 145, 110741, 2021 (SCI, IF 4). DOI: 10.1016/j.chaos.2021.110741 (First and corresponding Author)(Q1 Category ). (First and corresponding Author) (Q1 Category, Pages 19 Manuscript).
  • Neeraj Manhas and K. R. Pardasani  “Modelling Mechanism of Calcium oscillations in pancreatic acinar cells". Journal of Bioenergetics and Biomembranes, Springer. 46(3), 2014, 403-420. (SCI, IF=3). PMID: 25011561 DOI: 10.1007/s10863-014-9561-0.( First and corresponding Author) (Q1 Category, Pages 19 Manuscript).
  • Neeraj Manhas and K.R. Pardasani “Mathematical Model to study IP3 Dynamics Dependent Calcium oscillations in pancreatic acinar cell. JMIHI, American Scientific publisher.4,2014,874-880(7).(SCI,IF=1.00).doi: https://doi.org/10.1166/jmihi.2014.1333( First and corresponding Author) (Q2 Category, Pages 7 Manuscript)

 

  •  Manuscript under Preparation:

 

  • Details of Paper/Poster Presented in International conferences:
  • Manhas, N. Modeling the effects of VA on L-type Ca2+ channels and Ca2+ induced Ca2+ release in cardiac myocytes., Biophysical society 61th Annual meeting, February 11 to 15, 2017, New Orleans, Louisiana USA.
  • Manhas N, Camara AKS, and Dash RK, Modeling Mechanisms of Cardiac L-type Ca2+ Channel Regulation: Interactions by Voltage, Ca2+, and Isoflurane. Cardiac Physiome Society’s 20th meeting, Metabolism Mechanism and Excitation, 6 to 9 Nov. 2017, University of Toronto, Canada.
  •  Manhas N, Garcia G, Pannala VR, Kwok WM, Camara AKS, and Dash RK. Modeling the effects of volatile anesthetics on L-type Ca2+ channels and Ca2+ induced Ca2+ release in cardiac myocytes. Biomedical Engineering Society Meeting, Oct. 5 to 8, 2016. Minneapolis, USA.
  • Manhas N, and Pardasani K R “Modelling Mechanism of calcium oscillations in pancreatic acinar cells” 18th annual cum 3rd international conference of Gwalior Academy of Mathematical sciences (GAMS) on Mathematical, computational, and Integrative Sciences. “September 22 to 26, 2013, at National Institute of Technology Bhopal, India.

 

  • Details of Paper Presented in National Conferences: 
  • Manhas N and Pardasani.K.R “A mathematical model of Spatio-temporal calcium waves in pancreatic acinar cells”.  17th Annual conference of of Gwalior Academy of Mathematical sciences (GAMS) and National Symposium on Comptational Mathematics and information Technology” “December 7 to 9, 2012. (Jaypee University Gunna).

 

  •  International Training Programme / Workshop/ Conferences/ Symposium:
  • January 4 to 7, 2017, American Mathematical Society Annual Conference at Atlanta, at Hyatt Regency Atlanta and Marriott Atlanta Marquis USA.
  • June 20 to 25, 2016, Mathematical Modeling of Physiological Systems workshop organized by the American Mathematical Society (AMS), at Salt-Lake City, Utah, USA.
  • August 16 to 19, 2012, Elliptic and Parabolic Partial Differential equations and Related Topics: Theory and Numerical Method organized at Indian Institute of Technology Gandhinagar Ahmedabad, Gujrat, India.
  • January 15 to 23, 2011,DST-IISc-IISER Pune Workshop and Symposium on Mathematical Physiology held at Indian Institute Science Education & Research, Pune India.
  • February 25 to March 02, 2011. Stability and Bifurcation analysis and Pattern formation in Mathematics Ecology and Epidemiology held at the department of Mathematics and statistics, Indian Institute of Technology Kanpur, India.
  • Oct 22 to Nov. 5 2007, Instructional Workshop in Wavelets analysis Organized in the Department of Mathematics, Banaras Hindu University, India.

 

  • National/ Training Programme / Workshop/ Conferences/ Symposium: 
  • May 6 to 10, 2013, Short-term course on Finite Element Modelling with Matlab under (TEQIP II)  held at National Institute of Technology Bhopal, India.  
  • June 25 to July 4, 2012, 2-Weeks Workshop on Introduction to research methodologies conducted by Indian Institute of Technology, Bombay, India .  
  •  August 6 to 7, 2011, UGC Sponsored National Seminar on Recent Trends in Fluid Dynamics and Optimization Techniques and 15th Prof. P.D.Verma Memorial Lecture (NSRTFD and OT and PDVML-2011), Department of Mathematics University of Rajasthan, Jaipur India. 
Other Info.
  • Objective:

 

  • Academic Qualifications:
  • March 2015: Ph.D. in Applied Mathematics from the National Institute of Technology, Bhopal, (MANIT INDIA)  in the department of Mathematics. Thesis: Computational Models to study Calcium Dynamics in Pancreatic Acinar cell.  Mentor: Dr. Kamal Raj Pardasani. 
  • Worked with the group of calcium dynamics in the University of Auckland New Zealand, During my tenure of Ph.D. I visited in the University of Auckland and worked under the mentorship of Prof. James Sneyd.  
  • 2005 to 2007:  Post-Graduation from the Baba Ghulam Shah Badshah University, Jammu and Kashmir, India  185234, in Applied Mathematics.  
  • 2002 to 2005:  Graduation from Govt. Degree College, Kathua, Jammu University, India in Non-Medical.   
  • 2001 to 2002:  Higher Secondary (10 + 2) from Govt. Higher Secondary School Bhaddu, (J&K), Under Jammu and Kashmir State Board of School Education (JKBOSE), India.  
  • 1999 to 2000:  Matriculation (10th) from Govt. Higher Secondary School Bhaddu, (J&K), Under JKBOSE, India.

 

  • Research Experiences: As a Post Doc Fellow:
  • September 2019 to March 2021:  Independent Researcher at Alagappa University in the Department of Mathematics/ Ramanujan center for Higher Mathematics, under Rashtriya Uchchatar Shiksha Abhiyan (RUSA) government of India Grant. (RUSA grant/Fellowship is equivalent to Ramanujan or Inspire Fellowship).

 

  • June 2018  to August 2019: Post doc fellow at Michigan State University (USA) in the Department of Physiology,  worked in Mathematical/ Computational physiology. Mentor:Dr. Jason N Bazil.
  • Project details: Sponsored by National Institutes of Health (NIH) grant: My overall project entails the development and analysis of integrative computer models to investigate and characterize the molecular events that regulate calcium-dependent reactive oxygen species production from dysfunctional mitochondria in the reperfusion injury paradigm. I worked on the computational model of succinate dehydrogenase kinetics and reactive oxygen species production. This enzyme plays a key role in reperfusion injury, and my work will enable a quantitative and thorough analysis of the biochemical events that occur during this injury. However, my this work is published in Journal of Biological Chemistry. 

 

  • June 2015  to June 2018: Post doc fellow at Marquette University and Medical College of Wisconsin (USA) in the Department of Biomedical Engineering, worked in Mathematical/Computational physiology.
  • Project details: Sponsored by National Institutes of Health (NIH) grant: Worked on the mathematical modeling (spatial-temporal) of cardio myocytes electrophysiology and Ca2+ dynamics, incorporating sarcoplasmic reticulum- mitochondria micro domain and crosstalk in signal transduction and energy homeostasis, to study the mechanisms of cardio protective effects of volatile anesthetics (isoflurane). Specifically, I worked on the modelling of cardiac myocyte L-type calcium channel to understand: how both voltage dependent inactivation and calcium dependent inactivation modulate the L-type calcium channel  activity? how isoflurane a volatile anesthetic cardio protective agent, exerts negative inotropic effect on cardio myocyte  by modulating L-type calcium channel possibly by interacting with voltage dependent inactivation  and calcium dependent inactivation ? 

 

  • Research Interests:    
  • Spatial-temporal dynamics of Calcium dynamics, incorporating ER/SR mitochondria micro domain and crosstalk in signal transduction both in cardio myocytes cells /Excitable, and Pancreatic acinar cells/ Non Excitable cells.  
  • Development and analysis of integrative computer models to investigate and characterize the molecular events that regulate calcium-dependent reactive oxygen species production from dysfunctional mitochondria in the reperfusion injury paradigm. 
  • Modelling Cell Function and Mitochondrial Anesthetic Cardioprotection. 

 

  • Teaching Experiences:
  • Assistant Professor  from August 2021 - Present, Department of Mathematics at  National Institute of Technology Raipur, 492010, Chhattisgarh, India.
  • Teaching Assistant, from Dec 2009  to Nov 2014, Department of Mathematics at National Institute of Technology, Bhopal, 462003,during my Ph.D tenure. 
  • Lecturer, from July 2008 to Jan 2010, Department of Applied Mathematics at Hindustan College of Science and Technology Farah. Mathura Utter Pradesh (SGI Group). 

 

  • Travel Awards:  
  • Travel Grant of $1000 from the Mathematics Research Communities on Mathematics to attend American Mathematical Society Annual Conference at Atlanta 2017.  
  • Travel Grant of $1000 from the Mathematics Research Communities on Mathematics to attend Workshop/Conference  at Salt-Lake City, Utah. 
  • Travel Grant of $1000 from  the National Institutes of Health Grant to attend  Biophysical society 61th Annual meeting.  
  • Travel Grant of $1000 from the National Institutes of Health Grant to attend Biomedical Engineering Society meeting. 

 

  • Extra Activities: 
  • The National Cadet Corps in India is a voluntary organisation which recruits cadets from   high schools, higher secondary, colleges , and the universities all over india. The cadets are given basic military training in small arms and drill.  
  • Having “B” certificate in National Cadet Corps (NCC) Naval Unit.  
  • Having “A” certificate in National Cadet Corps (NCC) Army Unit.   
  •  In the annual event of the Baba Ghulam Shah Badshah University.  
  • Secured second position in presentation held at Baba Ghulam Shah Badshah University University (Annual Day 2006). 
  •  Secured second  position in sports held at Baba Ghulam Shah Badshah University (Annual Day 2006  in table tennis).  
  • Sole purpose of District Institute of Education and Trainings (DIET) is to conduct different kinds of training programmes to improve the quality of basic Education at school level.   
  • Secured second  position in Quiz (Science) held at District Institute of Education and Trainings Basholi, Kathua, India. 

 

  • Memberships. Have to be renewed: 
  • American Mathematical Society (AMS).  
  • Biomedical Engineering Society (BMES).

 

  • Fellowships:  
  • Institute Research Fellowship: By National Institute of Technology, Bhopal, India, from 2010 to 2014: (2010 to 2012) Junior Research Fellowship and (2012 to 2014) Senior Research Fellowship.   

 

  • Reviewer  for Prereviewed Journals:  
  • Royal Society of Chemistry Advances: An international journal to further the chemical sciences.  
  • Cardiovasc Endocrinol Metab.

 

  •  Invited talks:
  •  Delivered a talk at The Institute of Mathematical Sciences Chennai (Post doc talk), 2015 Title : Mathematical Physiology. 
  •  Delivered a talk at Indian Institute of Science Education and Research, Pune  (Post doc talk), 2015 Title : Mathematical Physiology.  
  • Delivered an expert talk in One Week Short-Term Training Program on Solution of Differential Equations and Its Applications (SDEIA), Organised by Department of Mathematics, Pandit Deendayal Petroleum University, Gandhinagar, Gujarat, India, during January 04-08, 2021.  Title : Mathematical Model of Intricate Calcium dynamics and Modulation of Calcium Signalling by Mitochondria in Pancreatic Acinar cells. 

 

  • Worked with: 
  • Prof. James Sneyd, Department of Mathematics The University of Auckland, New zealand.
  • Prof.  K.R.Pardasani, Department of  Applied Mathematics Maulana Azad National Institute of Technology,(MANIT), Bhopal, India.
  • Prof. Amadou K. S. Camara, Department of Anesthesiology, The Medical College of Wisconsin, USA.
  • Prof. Wai-Meng Kwok, Department of Anesthesiology, The Medical College of  Wisconsin, USA.
  • Jason Bazil, Ph.D. Assistant Professor, Department of Physiology,Michigan state University, USA.
  • Guilherme Garcia, Ph.D. Assistant Professor, Department of Biomedical Engineering and Department of Otolaryngology and Communication Sciences, Marquette University and The Medical College of Wisconsin, USA.